In Paul's letter to the Romans, he writes about the significance of Jesus Christ and what He did. Part of the reason why Jesus is important is that we have done some not-very-good stuff (AKA "sin") before, which does not look good in our record to God. In fact, God is very passionate regarding how people should not get screwed over by not-very-good actions -- hence the term "wrath of God" (the Greek word for "wrath", Strong 3709, can convey a sense of passion).
I know that wrath and sin are very difficult topics to talk about, but those two are important topics. Partly because sin ruins lives and that God does not want lives to be ruined by sin. And God's wrath isn't devaluing hate but more on a sense of passion to keep bad actions from recurring.
God's passion/wrath, specifically, is "against all ungodliness and unrighteousness of men" (1:18). The unrighteousness of men screws over other people (you can see examples of corruption in history and news), and considering that God has optimized plans to make sure that people don't get screwed over or screw over their lives, the ungodliness of men is basically rejecting God's optimized plans (resulting in a life that can, well, screw over people and even their own lives).
Then Paul talks about the significance of God even for people who don't believe in God in the first place. Paul wrote that from the creation, "His invisible attributes are clearly seen" and "being understood by the things that are made" (1:20). Even with years of modern science, there is still plenty of evidence of at least a universal Creator (rather than no god). In particular, modern science talks about how the universe started via Big Bang, and Big Bang implies that the universe has a starting point/trigger outside the universe and thus a Creator. Reasons to Believe took a look at evidence of God (even specifically, the God of Christianity) in this article. But not only that, the sense of good and evil can also serve as evidence of God. Yes, people disagree on moral views all the time, but there are at least some views that are basically universally held, like how it is not okay to randomly trip someone for no good reason.